Research & Technology

Spectrum Health researcher’s work on Vitamin B3 study featured in New England Journal of Medicine

Grand Rapids, Mich., Aug. 29, 2017– Paul Mark, MD, division chief of Spectrum Health Medical Group Medical Genetics, is among the researchers published in The New England Journal of Medicine regarding a ground-breaking study on the possible effects of vitamin B3, also known as niacin, on miscarriages and complex birth defects.

More than two dozen researchers contributed to the study, which originated at the Victor Chang Cardiac Research Institute in Sydney, Australia. The resulting article, “NAD Deficiency, Congenital Malformations, and Niacin Supplementation,” appeared in The New England Journal of Medicine on Aug. 10, 2017 and has since been cited in other reputable publications.

After determining through genomic testing that four children with similar and serious birth defects all had low levels of the NAD (nicotinamide adenine dinucleotide) enzyme due to genetic defects in the NAD+ Synthesis Pathway, researchers engineered mouse models with similarly low levels of the molecule and discovered that the mice also had similar birth defects. When the embryos were supplemented with niacin during gestation, NAD levels increased and the defects were not present.

“Next, we would like to evaluate the NAD levels in a larger number of children,” Dr. Mark said. NAD levels have been studied in adults while researching the aging process, but the levels have never before been studied in children.

Dr. Mark is the third Spectrum Health professional to be published this year in the peer-reviewed New England Journal of Medicine. His work, and the work of others, provides the research community with the opportunity to advance the practice of medicine, although any specific changes could be several years away.




Spectrum Health is a not-for-profit health system, based in West Michigan, offering a full continuum of care through the Spectrum Health Hospital Group, which is comprised of 12 hospitals, including Helen DeVos Children’s Hospital; 180 ambulatory and service sites; 3,600 physicians and advanced practice providers, including 1,500 members of the Spectrum Health Medical Group; and Priority Health, a health plan that served 996,000 members in fiscal year 2017. Spectrum Health is West Michigan’s largest employer, with 26,000 employees. The organization provided $372 million in community benefit during its 2017 fiscal year. Spectrum Health was named one of the nation’s 15 Top Health Systems—and in the top five among the largest health systems—in 2017 by Truven Health Analytics®, part of IBM Watson HealthTM. This was the sixth time the organization received this recognition.

Beth Cranson
Media Relations
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